QuoteIn PDT, photosensitizing chemicals that absorb light are injected into a tumor, which is then exposed to light. The chemicals generate oxygen radicals from the light energy, destroying the cancer cells. PDT is currently approved by the U.S. Food and Drug Administration (FDA) for the treatment of esophageal and lung cancer.
Rolf Saager, who works in the lab of Anthony Durkin at the Beckman Laser Institute at UC Irvine in collaboration with Kristen Kelly, M.D., and Modulated Imaging Inc., believes that PDT could also be used to treat skin cancer. But one obstacle to this application is the lack of a detailed imaging technique to target and monitor the effectiveness of PDT.
QuoteBut they discovered that the opposite experiment - over-expressing levels of pha-4 in the worms - increased longevity when on the restricted diet. "This is the first gene we have found that is absolutely essential to the longevity response to dietary restriction," explained Dr Dillin. "We finally have genetic evidence to unravel the underlying molecular programme required for increased longevity in response to calorie restriction."