One of my college friends uses what I believe is a Harmony One, and he's enamored with the thing. I only used it to fiddle around with his PS3, but it seemed pretty awesome from what I was able to tell.
Michael: Jodie, how's my schedule look for today? Jodie: You've got a conference and dinner party at the Japanese Embassy regarding wildlife protection. Michael: Oh, yeah...sorry, but I'll have to cancel that. I'm heading out to save America!